Small R01s for Clinical Trials Targeting Diseases within the Mission of NIDDK
National Institutes of Health (NIH)
Total funding ceiling of $200,000 per year
Maximum project period of three years
Encourages submission of pilot and feasibility clinical trials
Focus on diseases within the mission of NIDDK
Support for small, short-term proof-of-concept clinical trials
Researchers conducting clinical trials
Patients and communities affected by diabetes, digestive diseases, and kidney diseases
Eligible organization types include higher education institutions, nonprofits, for-profit organizations, small businesses, local, state, and federal governments, and tribal governments.
Non-domestic (non-U.S.) entities are not eligible to apply.
U.S.-based organizations are eligible.
Non-domestic components of U.S. organizations are not eligible.
Applications must propose clinical trials.
Trials should have clearly described aims and objectives.
Preliminary data regarding intervention efficacy are not required.
Direct costs limited to $200,000 per year.
Application deadline is May 7, 2026.
Applications must be submitted electronically.
No restrictions on prior grant funding mentioned.
Follow the instructions in the Research (R) Instructions in the How to Apply - Application Guide.
Applications will be evaluated based on scientific and technical merit.
Applications will undergo peer review and receive a written critique.
Scientific and technical merit of the proposed project will be considered.
Engagement with the relevant research population is expected.
Recruitment of participants must reflect the population at risk for the disease being studied.
Applications should align with the mission of NIDDK.
Applications that do not meet the eligibility criteria will be considered non-responsive.
Clearly defined aims and objectives are crucial.
Failure to comply with application instructions may lead to delays or rejection.
Engage with NIDDK staff early in the application process.
Highlight the potential impact on clinical practice and public health.