Cancer Center Support Grants (CCSGs)
National Institutes of Health (NIH)
Maximum award ceiling: $1,500,000
Initial budget period: 5 years, with a possibility of extension up to 7 years based on merit
To support NCI-designated Cancer Centers in conducting comprehensive cancer research.
To foster collaborative and transdisciplinary research that leads to advancements in cancer prevention, diagnosis, and treatment.
National Institutes of Health (NIH)
National Cancer Institute (NCI)
Cancer research community
Cancer patients and the public
Eligible organization types include higher education institutions, nonprofits, and government entities.
Specific institutions encouraged to apply include Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), and Tribal Colleges.
For new applications, a funding base of $10,000,000 for Clinical Cancer Centers or $6,000,000 for Basic Cancer Centers in annual direct costs of NIH funding is required.
Only U.S. organizations are eligible to apply.
Non-domestic (non-U.S.) entities are not eligible.
Projects must focus on cancer research and demonstrate a collaborative approach.
Centers must have a defined catchment area for their research and outreach activities.
Application budgets are not limited but must reflect the actual needs of the proposed project.
Funding base requirements must be met for eligibility.
Applications are due by 5:00 PM local time of the applicant organization on specified due dates.
The latest application deadline is January 7, 2026.
Only one application per institution is allowed, identified by a unique DUNS number.
Applications must follow the Multi-Project Instructions in the SF424 (R&R) Application Guide.
Specific programmatic instructions must be adhered to.
Applications will be evaluated based on scientific merit, organizational capabilities, and potential impact.
Standard review dates apply, with advisory council reviews following.
Priority will be given to applications demonstrating strong collaborative and transdisciplinary research.
Centers must demonstrate a commitment to community outreach and engagement.
Competition for funding may be high due to the number of eligible institutions.
Collaboration with other NCI-funded programs is encouraged.
Institutions with a strong track record in cancer research may have a competitive advantage.
Strong institutional commitment and adequate funding base are critical.
Failure to adhere to application guidelines may result in disqualification.
Engage in early discussions with NIH staff to clarify eligibility and application requirements.
Highlight unique strengths and collaborative efforts in the application.