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Grant Analysis

Purpose & Target

Core objective: Enhance the quality of life of older cancer patients (65 years and older) through pragmatic clinical trials focused on tailored nutritional care interventions.
Explicit identification of target recipient type and size: The call is open to a wide range of organizations and stakeholders including physicians, academia, SMEs, insurance companies, charities, foundations, research organizations, civil society, and regional/national health authorities.
MUST state if grant is 'SECTOR-SPECIFIC' or 'SECTOR-AGNOSTIC': SECTOR-SPECIFIC (Healthcare, Social Sciences and Humanities).
Geographic scope and any location requirements: EU Member States and Horizon Europe Associated Countries (specific eligibility details are defined in Annex B of the Work Programme General Annexes).
Key filtering criteria for initial grant screening: Focus on older cancer patients (65+), nutritional interventions validated through pragmatic clinical trials, and multi-stakeholder collaboration.
Grant frequency and program context: This is a specific topic within the annual Work Programme of the Horizon Europe Mission on Cancer, indicating a recurring program with potentially specific topics each year.

Financial Structure

Budget range per project: EUR 3,000,000 to EUR 5,000,000.
Total budget for this topic: EUR 15,000,000, with an expectation of 4 grants awarded.
Currency: EUR.
Eligible costs: Not explicitly detailed beyond Horizon Europe general rules. A budget for networking, attendance at meetings, and joint activities related to the 'Quality of Life' cluster is a mandatory eligible cost.
Financial and operational capacity requirements are described in Annex C of the Horizon Europe Work Programme General Annexes.
Legal and financial set-up of the grants is described in Annex G of the Horizon Europe Work Programme General Annexes.

Eligibility Requirements

Organizational Type and Capacity

Eligible entities include physicians, academia, patients and their caregivers, patient representatives, dietitians, nutritionists, behavioural scientists, SMEs, insurance companies, charities and foundations, research organisations, civil society, regional and national health authorities.
Applicants must demonstrate financial and operational capacity as described in Annex C of the Horizon Europe Work Programme General Annexes.

Geographic Location

Eligible countries are defined in Annex B of the Horizon Europe Work Programme General Annexes. This typically includes EU Member States and Horizon Europe Associated Countries.

Project Type

Proposals must be for 'Research and Innovation Actions' (RIA) focusing on pragmatic clinical trials.

Clinical Trial Specifics

Proposals must provide details of clinical studies using the template provided in the submission system.
Trials must be randomised or cluster-randomised academic investigator-initiated pragmatic clinical trials.
Translational research is limited to supporting the conduct and analyses of the proposed clinical trial(s).
Data must be disaggregated by sex, gender, age, and other relevant variables (e.g., socio-economic status, ethnicity).
The chosen nutritional care-centred intervention(s) should be adapted to the needs of older cancer patients and to the specificities of the provision of care at local, regional, or national level, duly reflecting cultural diversity. Affordability and accessibility should be considered.

Consortium Requirements

Proposals should include an appropriate mix of stakeholders from various disciplines and sectors.
Successful proposals will be required to join the 'Quality of Life' cluster for the Cancer Mission.

Application Process

Application Submission

Application deadline: 2025-09-16 00:00:00+00.
Submission format and platform: Applications are submitted via the Electronic Submission Service on the Funding & Tenders Portal.
Required documentation: The standard application form (HE RIA, IA) is available in the Submission System. Proposal page limits and layout are described in Part B of the Application Form.
Clinical studies details must be provided in a dedicated annex using the template from the submission system.

Evaluation Process

The indicative timeline for evaluation and grant agreement is described in Annex F of the Horizon Europe Work Programme General Annexes.
Evaluation uses a standard evaluation form (HE RIA, IA).

Post-Award Requirements

Successful proposals will be asked to join the 'Quality of Life' cluster for the Cancer Mission, established in 2023.
Projects should include a budget for networking, attendance at meetings, and joint activities with this cluster.

Evaluation Criteria

Award Criteria and Thresholds

Proposals will be evaluated based on 'Excellence', 'Impact', and 'Implementation'.
The threshold for each criterion will be 4.
The cumulative threshold for all criteria is 12.

Scope Alignment and Expected Outcomes

Projects must contribute to all expected outcomes:
- Improving older cancer patients' access to tailored nutritional care interventions for better treatment outcomes, symptom alleviation, survival, and quality of life.
- Providing evidence for national healthcare providers, policymakers, and authorities to implement tailored nutritional care as routine practice.

Methodology and Approach

Proposed pragmatic clinical trial(s) should be randomised or cluster-randomised and investigator-initiated.
Translational research should strictly support the conduct and analyses of the proposed clinical trial(s).
Trials should consider biological stratification of the patient population.
Primary and secondary endpoints (e.g., overall survival, patient-reported outcomes, quality of life) must be defined collaboratively with older patients and their caregivers, stimulating social innovation and end-user engagement using participative research models.

Stakeholder Engagement and Inclusivity

An appropriate mix of stakeholders from various disciplines and sectors (e.g., physicians, academia, patients/caregivers, SMEs, health authorities) must be included.
All data collected must be disaggregated by sex, gender, age, and other relevant variables such as socio-economic status or ethnicity.

Data Management and Open Science

All datasets produced should be described with metadata records in the EU dataset catalogue of the European Health Data Space.
All tools and models should leverage current European research infrastructures, follow open science principles, and be made available through the future UNCAN.eu platform.

Cross-Cutting Themes

Effective contribution of Social Sciences and Humanities (SSH) disciplines, experts, and expertise is required to enhance the societal impact of the related research activities.
Proposals should align with principles of artificial intelligence (AI) and the digital agenda, as part of cross-cutting priorities.

Compliance & Special Requirements

Regulatory and Ethical Compliance

Regulatory compliance, required permits, and authorizations for clinical trials involving human subjects are expected, following general Horizon Europe conditions.
Ethical standards are implied by the nature of clinical trials and Horizon Europe general rules.

Data Management and Open Science

All datasets produced must be described with metadata records in the EU dataset catalogue of the European Health Data Space.
All tools and models must leverage current European research infrastructures, follow open science principles, and be made available through the future UNCAN.eu platform.

Social Sciences and Humanities (SSH) Integration

Effective contribution of SSH disciplines and involvement of SSH experts, institutions, and relevant SSH expertise in the proposal is required to produce meaningful societal impact.

Cross-Cutting Priorities

Proposals should integrate Artificial Intelligence (AI) and digital transformation aspects where applicable, aligning with the EU's Digital Agenda.

Collaboration and Networking

Successful projects must join the 'Quality of Life' cluster for the Cancer Mission and dedicate budget for related networking and joint activities.

Risk Management

While not explicitly detailed, risk management expectations are standard for Horizon Europe grants, especially for clinical trials, and are part of general grant agreement requirements (Annex G).

Grant Details