Grant Details

Grant Analysis

Purpose & Target

This grant from the Medical Research Council (MRC) aims to fund a comprehensive programme of research in neurosciences and mental health. It is designed for established research organizations in the UK, with no upper limit on the funding amount, though applicants typically request £1 million or more. This is an ongoing funding opportunity, with a focus on advancing understanding, treatment, and prevention of disorders affecting the human nervous system.

Financial Structure

Funding Amount and Duration
  • Typical Funding: While there's no upper limit to the funding you can apply for, applicants typically apply for £1 million or more.
  • Duration: Programmes usually last five years, but you can contact MRC for advice if you want to propose a shorter or longer duration.
  • Funding Rate: MRC will usually fund up to 80% of your project's full economic cost (FEC). Your organization is responsible for securing the remaining balance (e.g., 20%) from other resources.
    • Exceptions: Certain eligible costs are funded at 100% FEC, including:
      • Costs for work undertaken at international organizations by international project co-leads (100% of eligible direct costs).
      • Costs for public partnerships/public contributors.
      • DNA sequencing (if carried out by an institution ineligible for UKRI funding).
      • Scheme-specific exceptional costs (e.g., for specific contract research organization activities exceeding £50,000 in Developmental Pathway Funding Scheme).
      • Externally contracted social surveys.
Eligible Costs Funding can be requested for a wide range of costs, provided they are justified, appropriate, and represent optimal use of resources. These include: * Staff Costs: A contribution to the salary of the Project Lead and Co-leads, and support for other research and technical staff (e.g., Research and Innovation Associates, Specialists, Technicians, Professional Enabling Staff). * For staff employed 100% on the project, visa fees and immigration health surcharge costs are eligible. * Salary costs for visiting senior collaborative researchers (up to one year) are eligible. * Research Consumables: Materials and supplies directly used in the research. * Equipment: Purchase of new equipment (including computers and software). Items costing over £25,000 should be listed under the equipment category; those under £25,000 are typically under 'directly incurred: other'. Costs for equipment repairs, major spares, external maintenance, and relocation are also eligible. Equipment for instrument development can be funded at 100% FEC. * Travel and Subsistence: For project staff, including for collaborative working visits, learning special techniques, and conference attendance (e.g., one UK/European conference annually, one major international conference every two years). Costs for additional caring responsibilities related to project travel are also eligible. * Data Costs: Data preservation, data sharing, and dissemination costs. This includes resources for managing, storing, analyzing, and providing access to data. * Estates and Indirect Costs: These are calculated by your research organization using the Transparent Approach to Costing (TRAC) methodology and are generally covered at 80% FEC. For international project co-leads from OECD DAC list countries (excluding India and China), overheads may be contributed at 20% of their directly incurred costs to develop research capacity. * NHS Research Costs: When directly associated with NHS studies. * Public Partnerships: Costs for public contributors, including time commitment, travel, and expenses. These are usually funded at 100% direct costs under 'Exceptions'. * International Collaborator Costs: Eligible costs for international project co-leads' work, including any locally employed staff at the international organization, travel, and other direct costs. The total for co-leads from high-income countries (not on OECD DAC List) including India and China must not exceed 30% of the total resources requested. There is no cap for co-leads from other DAC list countries. * Subcontractor Costs: For specific pieces of work delivered by a third-party organization, funded at 80% FEC. * Consultancy Fees: For specific contributions beyond the project team, funded at 80% FEC. Ineligible Costs Certain costs are explicitly not permitted and will be removed if included in your application: * Research involving randomised trials of clinical treatments. * Costs for PhD studentships (as these are funded through block grants to institutions). * Publication costs (e.g., article processing charges, book chapter charges) as these are covered by separate block grants to UK HEIs. * Funding to be used as a 'bridge' between grants. * General printing or postage costs not specific to the project. * Basic computing equipment for directly allocated staff, unless specifically justified. * General miscellaneous expenditure or contingency costs. * Carbon offsetting costs from project-related travel. * Patent costs and other intellectual property (IP) costs (universities receive separate funding for these). * Costs not sufficiently justified.

Eligibility Requirements

Organizational Eligibility
  • Eligible Organization Types: You must be employed at a research organization eligible to apply for Medical Research Council (MRC) funding. This generally includes: Higher Education Institutions (HEIs), research institutes, Public Sector Research Establishments, NHS bodies, and independent research organizations. Catapult Centres are also listed as eligible for UKRI funding.
  • Exclusions: You are not eligible if you lead a programme at an MRC institute or MRC partnership institute (like the Francis Crick Institute, Health Data Research UK, UK Dementia Research Institute).
  • Lead Applicant (Project Lead) Requirements:
    • You must be employed at an eligible research organization for the duration of the proposed project. If your contract ends before the project, your organization must confirm it will extend it.
    • You must demonstrate a substantial track record of securing funding and delivering high-quality research.
    • You must clearly show that you will direct the project and be actively engaged in the work.
    • Your application's focus must be explicitly within the science area of neurosciences and mental health.
    • You are generally not eligible to apply for this programme grant if you already hold an MRC programme grant, as MRC expects you to lead only one programme. Exceptions may be discussed with [email protected].
    • You are not eligible as a Project Lead if you are based at an international research organization, with the exception of MRC Unit The Gambia or MRC/UVRI Uganda Research Unit at the London School of Hygiene and Tropical Medicine.
  • International Co-Leads (Project Co-lead (international)):
    • Researchers from international research organizations can participate as Project Co-leads (international).
    • They must make a major intellectual contribution to the project's design or conduct.
    • Their organization must meet general equivalent requirements for UKRI funding eligibility (e.g., registered HEIs, research institutes, independent research organizations).
    • The UK lead organization is responsible for conducting due diligence on international partners.
  • Pre-application Stage: Crucially, you must complete a mandatory pre-application stage and be invited to submit a full application. Your organization must be registered on the new UKRI Funding Service. This is a hard requirement for eligibility to submit a full proposal.
Exclusion Criteria
  • Applications from Project Leads at MRC institutes or MRC partnership institutes are generally excluded.
  • Project Leads already holding an MRC programme grant are usually excluded.
  • International researchers cannot be the Project Lead (with the two specific exceptions noted).
  • Applications not aligned with neurosciences and mental health will be deemed out of scope.
  • Applications that attempt to fund PhD studentships or randomized trials of clinical treatments are ineligible for specific cost categories.

Application Process

Application Process & Timeline
  • Opening Date: 6 May 2025, 9:00am UK time
  • Pre-Application Deadline: The latest you can submit a pre-application for this opportunity is 7 July 2025.
  • Full Application Closing Date: 4 September 2025, 4:00pm UK time. Applications cannot be submitted after this time. Ensure you allow enough time for your research office's internal submission process.
  • Anticipated Start Date: Projects should aim to start one to six months after the funding decision date.
  • Assessment Timescale: MRC aims to complete the assessment process within six months of receiving your full application.
Application Stages
  1. Mandatory Pre-Application Stage: You must contact [email protected] before applying to check if your application is suitable. This pre-application involves submitting a brief description (up to four pages) outlining:
    • Proposed programme title, Project Lead, Co-leads, organizations, and estimated cost.
    • Justification for needing a programme grant, its strategic fit, suitability for major investment, long-term support, alignment with MRC strategy, and your team's track record.
    • For Longitudinal Population Studies (LPS), a specific pre-application process (LPS-SAP approval) is required.
  2. Invitation to Full Application: Only if you are invited via email after the pre-application stage can you proceed to the full application.
  3. Full Application Submission: Submitted through the new UK Research and Innovation (UKRI) Funding Service (not the Je-S system). The Project Lead is responsible, but all team members and partners are expected to contribute. Only the lead research organization can submit to UKRI.
Required Documentation and Materials (for Full Application)
  • Application Form: Completed directly in the Funding Service's text boxes.
  • Images: Can be used to convey important visual information (JPG, PNG, etc., <5MB), with descriptive captions; no sentences, paragraphs, or tables within images.
  • References: Included within the word count of the appropriate question sections, with hyperlinks where possible.
  • Summary (550 words): Plain English summary for reviewer identification and public availability (no confidential info).
  • Core Team: List key members, assigning roles (Project Lead, Project Co-lead (UK/International), Specialist, etc.). Only one Project Lead is allowed.
  • MRC Research Area (1 word): Select primary alignment.
  • MRC Grant Type (100 words): Justify why programme funding is needed, confirm pre-application completion, name MRC programme manager.
  • Vision (550 words): What you hope to achieve, quality, importance, knowledge advancement, timeliness, impact, benefits, fit with MRC strategy.
  • Approach (5,500 words): How you'll deliver, effectiveness, feasibility, risk management, methodology, previous work, translation of outputs, research environment, project plan (Gantt chart), diversity/inclusion in study population, use of male/female animals/tissues, public partnerships.
  • Reproducibility and Statistical Design (500 words): Ensure reliability and robustness, statistical analyses, methodology, experimental design, sample/effect sizes, bias mitigation, diversity reflection.
  • Data Management and Sharing (500-1,500 words): Detailed data management plan following MRC template, compliance with policies.
  • Applicant and Team Capability to Deliver (1,650 words): Why your team is right (experience, skills, leadership, positive research environment), using R4RI format (narrative CV).
  • Project Partners: Details on contributions (cash/in-kind) from collaborating organizations (not core team members).
  • Project Partners: Letters (or emails) of Support: Single PDF upload of letters/emails from each named partner, confirming commitment, value, relevance, benefits, additional value (max two A4 sides per partner). Industry partners must use a specific template and complete an ICF section.
  • Industry Collaboration Framework (ICF) (1,500 words): If applicable, confirm industry collaboration, follow ICF decision tree, answer questions on nature, goals, IP, dissemination, conflicts of interest.
  • Trusted Research and Innovation (TR&I) (100 words): If applicable, demonstrate how international collaboration in sensitive areas complies with TR&I principles (list countries, relevance to UK NSI Act).
  • Facilities (250 words): If required, provide name, usage, costs, and confirmation of agreement for use of UKRI or external facilities.
  • Ethics and Responsible Research and Innovation (RRI) (500 words): Identify and manage ethical/RRI implications.
  • Genetic and Biological Risk (700 words): Identify risks and mitigation for research involving GM organisms, plants, animals, microbes.
  • Research Involving Animals/Humans/Tissues (10/700 words each): Specific templates/statements/justifications for work under Animals Scientific Procedures Act, overseas animal research, human participation, or human tissues/biological samples.
  • Resources and Cost Justification (1,000 words): Justify all requested resources and costs, demonstrating comprehensiveness, appropriateness, and optimal use.
  • Clinical Research using NHS Resources (250 words): If applicable, complete and upload a Schedule of Events Cost Attribution Tool (SoECAT) export.
  • Related Applications (500 words): Details on related submissions to MRC or other funders, or if it's a resubmission (how feedback was addressed).
  • International Agreements (50 words): If applicable, identify which lead agency agreement (FAPESP, FNR, RCN) is being used.
Support Available
  • Application Assistance: Contact your research office for help with costings and writing your application.
  • Remit and Scientific Questions: Email [email protected].
  • General MRC Funding/Policy Questions: Email [email protected].
  • System/Submission Queries (Funding Service): Email support@funding-service.ukri.org or call 01793 547490.
  • Disability and Accessibility Support: UKRI offers support during the application and assessment process.

Evaluation Criteria

The assessment process is highly competitive and comprehensive, involving expert review and panel evaluation. Key areas of assessment include:
  • Vision of the Project: Assessors will look for:
    • Quality and Importance: Is the proposed work of excellent quality and importance within or beyond its fields?
    • Advancement of Knowledge: Does it have the potential to advance current understanding or generate new knowledge, thinking, or discovery?
    • Timeliness: Is the research timely given current trends, context, and needs?
    • Impact: How will it impact world-leading research, society, the economy, or the environment?
    • Benefits: Clear identification of potential direct or indirect benefits and beneficiaries, particularly improvements in human or population health.
    • Strategic Fit: How well does the programme fit within the MRC strategy and what difference will it make?
  • Approach to the Project: This is a critical section, evaluated on:
    • Effectiveness and Appropriateness: Is the design effective and appropriate to achieve objectives?
    • Feasibility and Risk Management: Is it feasible, with comprehensive identification of risks and mitigation strategies?
    • Methodology: Use of clearly written and transparent methodology (if applicable).
    • Progression: How does it build upon and progress from previous work?
    • Translation of Outputs: Maximizing translation of outputs into outcomes and impacts.
    • Research Environment: Contribution of the research environment (place and relevance) to success.
    • Resources and Facilities: Demonstration of access to appropriate services, facilities, infrastructure, or equipment.
    • Project Plan: Inclusion of a project plan with milestones and timelines (e.g., Gantt chart).
    • Diversity and Inclusion: Justification of how diversity and inclusion will be approached in the study population, adhering to the MRC embedding diversity in research design policy (if applicable).
    • Sex in Experimental Design: Justification for the use of male and female animals or tissues/cells, or clear justification if not.
    • Public Partnerships: Explanation and justification of public partnerships and their added value.
  • Reproducibility and Statistical Design: Evaluated for reliability, robustness, and reproducibility, including:
    • Methodology and Experimental Design: Details on statistical analyses, methodology, and experimental design (beyond the main approach section).
    • Expert Advice: Evidence of seeking professional statistical or other relevant advice.
    • Specifics: Sample and effect sizes, planned statistical analyses, models chosen, potential sources of bias and mitigation, reflection of diversity in experimental design and analyses.
  • Applicant and Team Capability to Deliver: Assessors seek evidence of:
    • Relevant Experience: Appropriate to career stage.
    • Balance of Skills: Right balance of skills and expertise for the proposed work.
    • Leadership and Management: Appropriate leadership and management skills, and approach to developing others.
    • Research Environment Contribution: Contribution to developing a positive research environment and wider community.
    • R4RI Format: Use of the Résumé for Research and Innovation (R4RI) format to showcase contributions across various areas (new ideas, development of others, wider community, societal benefit).
  • Ethical and Responsible Research and Innovation (RRI) Considerations: Demonstrated identification and evaluation of ethical/RRI implications and issues, and how they will be managed.
  • Resources Requested: Evaluation of whether the requested resources are:
    • Comprehensive, Appropriate, and Justified: Particularly for more costly items like staff, significant travel, equipment over £25,000, consumables beyond typical, facilities, exceptions, public and patient involvement, data management, international co-leads.
    • Optimal Use: Represents the optimal use of resources to achieve intended outcomes.
    • Maximizing Impact: Maximizes potential outcomes and impacts.
  • Data Management and Sharing: The data management plan will be assessed for clarity and compliance with MRC's published policies, demonstrating how data will be managed and shared (e.g., for population cohorts, genetic data, human participants).
  • Industry Collaboration Framework (ICF) and Trusted Research and Innovation (TR&I): If applicable, compliance with ICF for industry partners (nature, goals, IP, dissemination restrictions, conflicts of interest) and TR&I principles for international collaborations (listing countries, relevance to UK NSI Act, risk management) will be assessed.

Compliance & Special Requirements

Regulatory Compliance and Ethical Standards
  • Organizational Eligibility: Your research organization must be formally eligible for MRC funding, and by applying, confirms acceptance of MRC award terms and conditions, including UKRI FEC grants terms.
  • Ethical Review: You must identify, evaluate, and manage all relevant ethical and responsible research and innovation (RRI) considerations, demonstrating compliance with MRC guidance on ethics and approvals.
  • Animal Research: If involving vertebrate animals or other organisms covered by the Animals Scientific Procedures Act, adherence to specific templates and justification of severity, approvals, species, and experimental design is required. Overseas animal research must meet UK welfare standards.
  • Human Participation/Tissues: Research involving human subjects, personal information, human tissues, or biological samples requires details on approving bodies, justification of numbers/diversity/procedures, and confirmation of approvals.
  • Genetic/Biological Risk: Identification of genetic and biological risks and planned mitigation for research involving genetically modified organisms.
  • Data Protection & Sharing: Compliance with MRC's published data management and sharing policies is mandatory. A detailed data management plan (DMP) is required, especially for human data, cohorts, and clinical trials (requiring ISRCTN registration and timely reporting).
  • NHS Research: For clinical research using NHS resources, completion and upload of a Schedule of Events Cost Attribution Tool (SoECAT) is typically required to ensure eligibility for NIHR support.
Special Considerations & Strategic Alignment
  • Mandatory Pre-Application: This is a strict requirement; a full application will only be accepted if invited after a successful pre-application.
  • Programme Grant Justification: You must clearly justify why your proposed work requires programme-level funding (as a coordinated, coherent group of related projects requiring long-term, extensive support) and how it fits an MRC area of high strategic priority.
  • Equality, Diversity, and Inclusion (EDI): MRC is committed to EDI and encourages applications from a diverse range of researchers, supporting flexible working, career breaks, and caring responsibilities. EDI considerations are part of the assessment criteria (e.g., embedding diversity in research design, public partnerships).
  • Trusted Research and Innovation (TR&I): If your proposed work involves international collaboration in sensitive research or technology areas, you must demonstrate how it complies with UKRI's TR&I principles, identifying potential risks (e.g., related to the 17 areas of the UK National Security and Investment (NSI) Act) and mitigation controls.
  • Industry Collaboration Framework (ICF): If collaborating with industry or company project partners, you must comply with the MRC ICF, detailing IP arrangements, restrictions on dissemination, and conflicts of interest.
  • Open Access Policy: Applicants are generally not permitted to include publication costs (e.g., APCs) in their grant application, as these are handled via institutional block grants.
  • Resubmission Policy: Unsuccessful applications will not be reconsidered within 12 months unless specifically invited to resubmit.
  • Strategic Fit: Programme proposals are a large investment for the MRC, and applicants are expected to show clear alignment with the MRC strategy and its Neurosciences and Mental Health Board's aims.
  • Project Partner Agreements: Formal collaboration agreements (e.g., for IP) are required for audit purposes if an award is made. Project partners must provide letters of support, and for industry partners, additional ICF information.
  • COVID-19 Impact: Reviewers and panel members will be advised to consider the unequal impacts of COVID-19-related disruption on applicants' track records and career development, ensuring no penalty for such disruptions.

Grant Details

neurosciences mental health brain disorders neurology neurodegeneration neuroinflammation addictions substance misuse behavioural disorders autism cognitive neuroscience sensory neuroscience neurobiology neurophysiology neuroimaging brain banking neuroinformatics medical research health research program grant ukri mrc research funding longitudinal studies population studies research organization uk international collaboration fec funding strategic research innovation capacity building ethical research data management
Neurosciences and mental health: programme
OPP968
UKRI
UNIVERSITY PUBLIC OTHER
GB
HEALTHCARE TECHNOLOGY EDUCATION
DEVELOPMENT GROWTH
OTHER
SDG3 SDG4 SDG9
FUNDING RESEARCH_DEVELOPMENT CAPACITY_BUILDING
None
None
1000000.00
None
GBP
80.00
Sept. 4, 2025, 3 p.m.
Within 6 months from submission