Grant name: Grand Opportunity in Medications Development for Substance-Use Disorders (U01 Clinical Trial Optional)
Funding organization: National Institutes of Health (NIH)
Total funding amount: Up to $5 million per year
Duration: Maximum of 3 years
Primary objective: Support research to advance the development of safe and effective medications for the treatment of Substance Use Disorders (SUD).
Key stakeholders: National Institute on Drug Abuse (NIDA), researchers, and organizations involved in SUD treatment.
Funding source: Federal government.
Funding type: Cooperative agreements.
Significance: Addresses urgent public health needs for effective SUD treatments.
Grant frequency: Recurring.
Higher Education Institutions
Public/State Controlled Institutions of Higher Education
Private Institutions of Higher Education
Nonprofits Other Than Institutions of Higher Education
For-Profit Organizations
Small Businesses
Local Governments
State Governments
County Governments
City or Township Governments
Indian/Native American Tribal Governments (Federally Recognized)
Indian/Native American Tribal Governments (Other than Federally Recognized)
Federal Government Agencies
U.S. Territories or Possessions
Other: Independent School Districts, Public Housing Authorities, Faith-based Organizations, Regional Organizations, Foreign Organizations.
Organizations must complete registrations with System for Award Management (SAM), eRA Commons, and Grants.gov.
All Program Directors/Principal Investigators (PDs/PIs) must have an eRA Commons account.
Focus on developing compounds for treating SUDs including opioids, methamphetamine, cocaine, nicotine, and cannabis.
Applications must provide entry and exit points in the FDA approval pathway.
Advancement of medications closer to FDA approval.
High-impact studies yielding necessary results.
Research in chemistry, pharmaceutics, preclinical and clinical development.
Use of AI/ML tools for medication development.
Application budgets are limited to $5 million per year.
No cost-sharing required.
Application due date: August 11, 2025.
Earliest start date: April 10, 2025.
Compliance with NIH Grants Policy Statement.
Adherence to ethical standards and regulations.
Applications must be submitted electronically via Grants.gov.
Follow the instructions in the How to Apply - Application Guide.
Applications evaluating psychosocial interventions will not be reviewed.
Applications addressing alcohol as the only substance of use will not be reviewed.