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Grant Analysis

Purpose & Target

The core objective of this grant is to advance scientific understanding of minority health and health disparities by funding research focused on family health, well-being, and resilience. This research aims to develop interventions at the interpersonal and family levels.

Target Recipient Type: Primarily research organizations, including universities, non-profits, and certain for-profit entities, that conduct biomedical, clinical, population, behavioral, or social sciences research.
Target Size: SECTOR-SPECIFIC in healthcare and social sciences.
Geographic Scope: Projects must focus on families from NIH-designated populations experiencing health disparities in the United States. Foreign organizations are not eligible to apply for funding.
Key Filtering Criteria: Research must involve family-level studies and address health disparities. Must include measures for at least two family members.
Grant Frequency: This is a recurring funding opportunity, a reissue of a previous PAR (PAR-21-358).

Financial Structure

Funding Instrument: This opportunity provides a Grant, which is a direct financial assistance mechanism.
Budget: Application budgets are not limited; however, they must accurately reflect the actual needs of the proposed research project.
Project Period: The maximum allowable project period is 5 years.
Cost Sharing: Cost sharing or matching funds are not required for this funding opportunity.
Pre-award Costs: Pre-award costs are only allowable as outlined in the NIH Grants Policy Statement Section 7.9.1.
Financial Reporting: Recipients are required to submit an annual Research Performance Progress Report (RPPR) and financial statements. A final RPPR, invention statement, and expenditure data are required for project closeout.

Eligibility Requirements

Organizational Types

Public/State Controlled Institutions of Higher Education
Private Institutions of Higher Education
Nonprofits with 501(c)(3) IRS Status
Nonprofits without 501(c)(3) IRS Status
Small Businesses
For-Profit Organizations (other than Small Businesses)
State Governments
County Governments
City or Township Governments
Special District Governments
Indian/Native American Tribal Governments (Federally Recognized)
Indian/Native American Tribal Governments (Other than Federally Recognized)
Eligible Agencies of the Federal Government
U.S. Territory or Possession
Independent School Districts
Public Housing Authorities/Indian Housing Authorities
Native American Tribal Organizations (other than Federally recognized tribal governments)
Faith-based or Community-based Organizations
Regional Organizations

Geographic Restrictions

Foreign organizations (non-U.S. entities) are not eligible to apply.
Non-U.S. components of U.S. organizations are not eligible to apply for funding. However, foreign components within the research (defined by NIH) are allowed if they contribute to U.S. minority health/health disparities knowledge.

Registration Requirements

Must complete and maintain active registration in the System for Award Management (SAM), requiring annual renewal.
Must obtain a Unique Entity Identifier (UEI) as part of SAM.gov registration.
Must register with eRA Commons (both organizational and individual PD/PI accounts).
Must register with Grants.gov.
All required registrations must be completed before submitting the application (can take 6 weeks or more).

Individual Eligibility (Program Director/Principal Investigator - PD/PI)

Any individual with the necessary skills, knowledge, and resources can serve as PD/PI.
PD/PIs must have an eRA Commons account.
For multiple PDs/PIs, adhere to the NIH Multiple Program Director/Principal Investigator Policy.

Project Scope Limitations

Projects must focus on families from one or more NIH-designated populations experiencing health disparities in the U.S.
Projects must include family health measures (e.g., health outcomes or behaviors for two or more family members).
Studies using animal models will not be supported under this grant.

Application Process

Application Types Allowed

New applications
Renewal applications (for ongoing projects)
Resubmission applications (revised previous submissions)
Revision applications (to modify existing awards)

Submission Method

All applications must be submitted electronically. Paper applications will not be accepted.
You can use NIH ASSIST, Grants.gov Workspace, or an institutional system-to-system (S2S) solution.

Key Dates

Posted Date: December 13, 2024
Open Date (Earliest Submission): January 05, 2025
Latest Application Due Dates (by 5:00 PM local time of applicant organization):
- New Applications: February 05, 2027
- Renewal / Resubmission / Revision Applications: March 05, 2027
- AIDS-related New/Renewal/Resubmission/Revision Applications: May 07, 2027
Expiration Date for this funding opportunity: May 08, 2027

Submission Requirements

Follow all instructions in the 'Research (R) Instructions' section of the 'How to Apply - Application Guide', unless specifically overridden by this announcement.
Adhere strictly to all conformance requirements; non-compliant applications may be delayed or not reviewed.
All page limitations specified in the 'How to Apply - Application Guide' and 'Table of Page Limits' must be observed.
Specific forms (SF424(R&R) series, R&R/Modular Budget, PHS 398 series) must be completed as per the Application Guide.
The PHS 398 Research Plan must specifically describe how the project advances knowledge of family-level health disparities, include a detailed conceptual model, and address multidisciplinary expertise.
For projects with foreign components, describe how activities contribute to U.S. minority health/health disparities knowledge.
If applicable, detail how community partners participated in the research conceptualization, planning, and implementation.
A Resource Sharing Plan and a Data Management and Sharing Plan are required (the latter for all research generating scientific data, regardless of cost).
The Appendix has strict limitations; no publications or other materials are allowed, except for blank questionnaires or surveys.
PD(s)/PI(s) must include their eRA Commons ID in the Senior/Key Person Profile form.
The applicant organization's Unique Entity Identifier (UEI) must match identifiers used in SAM and eRA Commons.

Application Support

Contacts are available for eRA Service Desk, general grants information, Grants.gov Customer Support, Scientific/Research questions, Peer Review inquiries, and Financial/Grants Management.

Process Notes

It is highly recommended to submit applications early to allow time for correcting any submission errors.
Applications requesting $500,000 or more in direct costs in any single year (excluding consortium F&A) must contact a Scientific/Research Contact at least six weeks before submission.
If a due date falls on a weekend or federal holiday, the deadline is automatically extended to the next business day.
Applicants are responsible for verifying successful submission by viewing their application in eRA Commons before the deadline.

Evaluation Criteria

Applications are reviewed for scientific and technical merit to assess their potential for significant impact. Overall Impact Score

Reviewers provide an overall impact score reflecting the likelihood of the project to exert a sustained, powerful influence on the research field(s).

Scored Review Criteria These three factors directly contribute to the scientific merit score and overall impact: - Importance of the Research (Significance and Innovation): How important and innovative is the proposed research in advancing the field? - Rigor and Feasibility (Approach): How well-designed, rigorous, and feasible is the proposed research approach? - Expertise and Resources (Investigator(s) and Environment): Do the investigators have the necessary expertise, and is the research environment suitable for the project? Additional Review Criteria (Not Scored, but Considered for Overall Impact)

Protections for Human Subjects: Adequacy of plans to protect human participants.
Vertebrate Animals: Justification for animal use, appropriateness of species, and measures to minimize discomfort (if applicable).
Biohazards: Assessment of hazardous materials/procedures and proposed protections (if applicable).
Resubmissions: Evaluation of the entire revised application.
Renewals: Assessment of progress made in the previous funding period.
Revisions: Evaluation of whether the proposed expansion of the project's scope is appropriate.

Additional Review Considerations (Not Scored)

Study Timeline: For clinical trials, detailed, feasible, and justified timeline, including start-up, enrollment rates, and follow-up. Discussion of potential challenges and solutions.
Authentication of Key Biological and/or Chemical Resources: Plans for validating these resources.
Budget and Period of Support: Justification and reasonableness of the proposed budget and project duration in relation to the research.

Review and Selection Process

Applications undergo scientific peer review by Scientific Review Groups. Only applications deemed to have the highest scientific and technical merit (typically the top half) will proceed to discussion and receive an overall impact score.
Funding decisions are based on: 1) Scientific and technical merit (from peer review), 2) Availability of funds, and 3) Relevance of the project to the program's priorities.

Compliance & Special Requirements

Regulatory Compliance

All awards are subject to the terms and conditions outlined in the NIH Grants Policy Statement, including cost principles.
Recipients must comply with all applicable non-discrimination laws and submit an Assurance of Compliance (HHS-690).
Compliance with all federal statutes and regulations related to federal financial assistance is mandatory.
If the award involves health IT implementation/acquisition/upgrades, the technology must meet specific standards (45 CFR part 170, Subpart B) and, for certain clinical settings, be ONC Health IT Certified.

Data and Privacy

Organizations with consistent access to HHS systems or personal identifiable information (PII)/personal health information (PHI) from HHS must develop cybersecurity plans and procedures modeled after the NIST Cybersecurity framework.
Recipients must adhere to and implement their approved Data Management and Sharing Plan for any research generating scientific data.

Human Subjects & Clinical Trials

Registration and results reporting for all clinical trials are expected on ClinicalTrials.gov.
All research protocols involving human subjects must receive approval from an Institutional Review Board (IRB) or Independent Ethics Committee (IEC).
Recipients must provide NIH with documents detailing any major changes to ongoing protocols.
Data and Safety Monitoring requirements apply to all human biomedical and behavioral intervention studies.
Clinical research involving investigational interventions (drugs, vaccines, devices) requires compliance with Food and Drug Administration (FDA) Investigational New Drug (IND) or Investigational Device Exemption (IDE) requirements.

Intellectual Property

An invention statement is required during the closeout phase of the grant, indicating compliance with intellectual property policies.

Special Considerations

Research should align with the NIMHD Research Framework, encouraging multidisciplinary approaches and integrating factors at multiple levels (e.g., biological, behavioral, socio-cultural, environmental).
Studies involving primary data collection with human participants are strongly encouraged to use Social Determinants of Health measures from the PhenX Toolkit.
A life course perspective is encouraged, with interventions focusing on transition points across the lifespan.
The use of health information technology applications (wearables, decision aids, health information portals) and/or social media elements to improve family health is encouraged.
Collaborations with community organizations, clinicians, public health, social/human service organizations, special interest groups, and faith-based organizations are encouraged.
Involvement of key community members in research conceptualization, planning, and implementation is encouraged (but not required).
This funding opportunity is not subject to intergovernmental review (E.O. 12372).
Recipients must disclose any federal criminal law violations (fraud, bribery, gratuity) that could affect the federal award.

Grant Details