Leveraging Network Infrastructure to Conduct Innovative Research for Women, Children, Pregnant and Lactating Women, and Persons with Disabilities (UG3/UH3 - Clinical Trial Optional)
National Institutes of Health (NIH)
Total funding amount: up to $6,250,000
Project duration: up to 7 years (UG3 phase: up to 2 years; UH3 phase: up to 5 years)
To leverage NICHD clinical research network infrastructure for innovative, multisite, investigator-initiated clinical trials and observational studies.
The mission is to improve health outcomes for targeted populations, including women, children, pregnant and lactating women, and persons with disabilities.
Key stakeholders include NICHD, NIH, and the extramural research community.
Beneficiaries include women, children, pregnant and lactating women, and persons with disabilities.
Eligible organization types include higher education institutions, nonprofits, for-profit organizations, local governments, state governments, and tribal governments.
Non-domestic (non-U.S.) entities are not eligible to apply.
Applications must utilize NICHD-supported Network infrastructure.
Non-domestic components of U.S. organizations are eligible to apply.
Applications must address specific aims and milestones for both UG3 and UH3 phases.
Preference will be given to large scale clinical trials.
Direct costs are limited to $6,250,000 for the entire project period.
Projects requiring direct costs exceeding this amount may be proposed but require additional NICHD approval.
Application due dates are set for various cycles, with the latest deadline being November 15, 2027.
All applications are due by 5:00 PM local time of the applicant organization.
Applicant organizations may submit more than one application, provided each is scientifically distinct.
The NIH will not accept duplicate or highly overlapping applications under review at the same time.
Applications must follow the instructions in the Research (R) Instructions in the How to Apply - Application Guide.
A Data Management and Sharing Plan (DMS Plan) is required.
Applications will be evaluated for scientific and technical merit through the NIH peer review system.
Applications will undergo a rigorous pre-application process to assess scientific scope and feasibility.
Strong preference will be given to studies that optimize participant enrollment and utilize innovative study designs.
Applications must be submitted as investigator-initiated, multi-Project Director/Principal Investigator (PD/PI) grant applications.
Applications proposing single center, animal studies, or basic science are beyond the scope of this NOFO.
Applications should align with one or more of the participating Networks and their corresponding scientific areas of interest.
Utilizing NICHD Network infrastructure may provide a competitive advantage in the application process.
Meeting milestones throughout both UG3 and UH3 phases is critical for continued funding.
Ensure compliance with all application instructions to avoid delays or non-acceptance.
Engage with NICHD staff early in the application process for guidance.
Highlight innovative aspects of the proposed research and alignment with NICHD priorities.