Grant name: Development of Medications to Prevent and Treat Substance Use Disorders and Overdose (UG3/UH3 - Clinical Trial Optional)
Funding organization: National Institutes of Health (NIH), National Institute on Drug Abuse (NIDA)
Total funding amount: Up to $3 million per year for direct costs
Duration: Maximum project period of 5 years
Primary objective: To support research for the discovery and development of medications to prevent and treat SUDs and overdose
Funding source: Federal government
Funding type: Cooperative agreement
Significance: Addresses the urgent need for effective medications to combat the substance use crisis
Grant frequency: Recurring
Higher Education Institutions
Public/State Controlled Institutions of Higher Education
Private Institutions of Higher Education
Nonprofits (with and without 501(c)(3) status)
For-Profit Organizations (including Small Businesses)
Local, State, County, City or Township Governments
Indian/Native American Tribal Governments (both Federally Recognized and Other)
Federal Government Agencies
U.S. Territories or Possessions
Other entities including Independent School Districts, Public Housing Authorities, Faith-based Organizations, and Foreign Organizations
Preclinical and clinical research studies aimed at advancing medications for SUD and overdose
Focus on new chemical entities, biologics, and repurposed medications
Specific interest in compounds that prevent initiation and progression of SUDs, improve treatment adherence, and reduce overdose risks
Investigators must have the skills and resources necessary to conduct the proposed research
Applications must include a detailed research strategy and milestones for both UG3 and UH3 phases
Application budgets are limited to $3 million per year for direct costs
No cost-sharing is required
Open Date: March 10, 2025
Application Due Date: August 11, 2025
Expiration Date: August 12, 2025
Applicants must comply with NIH Grants Policy Statement and federal regulations
Required registrations include System for Award Management (SAM), eRA Commons, and Grants.gov
Applications must be submitted electronically via Grants.gov or NIH ASSIST
Compliance with application instructions is strictly enforced