Grant Details

General Overview

Grant Information

Grant name: HEAL Initiative: Studies to Enable Analgesic Discovery

Funding organization: National Institutes of Health (NIH)

Total funding amount: $2,500,000

Duration: Up to 3 years

Primary objective: To support research for non-opioid and non-addictive treatments for pain.

Mission statement: Part of the NIH Helping to End Addiction Long Term (HEAL) initiative.

Key stakeholders: NIH, various institutes including NINDS, NEI, NIA, NIAAA, NIAMS, NICHD, NIDCR, NIDDK, NCCIH, NCI.

Beneficiaries: Researchers and patients suffering from chronic pain.

Funding source: NIH.

Funding type: Grant.

Significance: Addresses the opioid crisis by promoting alternative pain management strategies.

Grant frequency: One-time funding opportunity.

Organizational Aspects

Eligible Organization Types

Higher Education Institutions

Public/State Controlled Institutions of Higher Education

Private Institutions of Higher Education

Nonprofits Other Than Institutions of Higher Education

For-Profit Organizations

Small Businesses

Local Governments

State Governments

County Governments

City or Township Governments

Indian/Native American Tribal Governments (Federally Recognized)

Indian/Native American Tribal Governments (Other than Federally Recognized)

Federal Government Agencies

U.S. Territory or Possession

Independent School Districts

Public Housing Authorities/Indian Housing Authorities

Faith-based or Community-based Organizations

Regional Organizations

Ineligible Organizations

Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.

Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.

Scope and Focus

Primary Focus Areas

Development and validation of assays for drug discovery.

Identification and characterization of potential therapeutic agents including small molecules, biologics, and natural products.

Projects focused on various pain conditions including acute pain, chronic pain, and pain co-occurring with substance use disorders.

Technical Details

Technical Expertise Requirements

Strong biological rationale for the intended approach.

Preliminary data reflecting rigorous, well-designed experiments.

Financial Structure

Budget and Funding

Application budgets limited to direct costs of $350,000 per year.

Total project period not exceeding three years.

Timeline and Implementation

Key Dates

Open Date: December 28, 2024

Application Due Dates: Various dates from January 16, 2025, to September 17, 2026.

Expiration Date: January 16, 2027.

Compliance and Requirements

Regulatory Compliance

Must comply with NIH Grants Policy Statement.

No cost sharing required.

Application Process

Submission Instructions

Applications must be submitted electronically through Grants.gov.

Follow instructions in the Research (R) Instructions in the How to Apply - Application Guide.

Grant Details

pain management drug discovery non-opioid treatments healthcare research biologics small molecules natural products clinical research translational research
HEAL Initiative: Studies to Enable Analgesic Discovery
RFA-NS-25-023
NIH HEAL Initiative
EDU NGO ENTERPRISE PUBLIC RESEARCH SME OTHER
US
HEALTHCARE OTHER
DEVELOPMENT OTHER
0-10 11-50 51-250 251-500 500+
SDG3
FUNDING RESEARCH_DEVELOPMENT
None
2500000.00
350000.00
350000.00
USD
100.00
Sept. 17, 2026, 10 p.m.
March 2025 - July 2025