Chemical Countermeasures Research Program (CCRP) Initiative
National Institutes of Health (NIH)
Estimated funding amount: $300,000 per project
Maximum project duration: 5 years
To support research on the deleterious effects of acute exposure to Ultra-Potent Synthetic (UPS) opioids.
To develop new knowledge and approaches related to the prevention, diagnosis, treatment, etiology, and consequences of drug abuse and addiction.
Researchers in neuroscience, biomedical, behavioral, and social sciences.
Public health officials and organizations involved in drug abuse prevention and treatment.
Eligible organization types include higher education institutions, nonprofits, for-profit organizations, local and state governments, and tribal governments.
Non-domestic (non-U.S.) entities are not eligible to apply.
Organizations must be based in the U.S. or its territories.
Non-domestic components of U.S. organizations are not eligible.
Research must focus on the mechanisms and health impacts of acute exposure to UPS opioids.
Applications must include at least one opioid identified as a chemical of concern by the Department of Homeland Security.
Application budgets are limited to $300,000 direct costs per year.
Application due date: November 18, 2027.
Earliest start date for funded projects: November 18, 2025.
Applicant organizations may submit more than one application, provided each is scientifically distinct.
Applications must follow the instructions in the Research (R) Instructions in the How to Apply - Application Guide.
Applications will be evaluated based on scientific merit, innovation, and feasibility.
Applications will undergo a scientific peer review process.
Scientific and technical merit of the proposed project will be a primary consideration.
Applications must focus on the DHS list of chemicals of concern.
Applications not responsive to the NOFO will not be reviewed.
Research should align with public health priorities regarding opioid exposure.
Innovative approaches to understanding opioid toxicity may enhance competitiveness.
Clear articulation of research objectives and methodologies.
Submitting applications that do not comply with the guidelines.
Engage with NIH contacts for guidance prior to submission.
Highlight innovative aspects of the proposed research.