Grant Details

General Overview

Grant Name and Funding Organization

Advancing Research on Alzheimer's Disease (AD) and AD-Related Dementias (ADRD)

National Institutes of Health (NIH)

Total Funding Amount and Duration

Total funding amount is approximately $4 million for fiscal year 2023.

Individual awards up to $500,000 for Phase I and $2.5 million for Phase II.

Primary Objective and Mission Statement

Support research that may lead to the development of innovative products and/or services for preventing and treating Alzheimer's disease and related dementias.

Key Stakeholders and Beneficiaries

Small business concerns (SBCs) in the United States.

Individuals living with Alzheimer's disease and related dementias.

Grant Program Context and History

Reissue of PAS-19-317.

Aligned with agency priorities and recommendations from the National Alzheimer’s Project Act.

Funding Source and Type

Funded by the National Institute on Aging (NIA) and National Institute of Neurological Disorders and Stroke (NINDS).

Type: Small Business Technology Transfer (STTR) Grant.

Significance within Funding Landscape

Addresses critical barriers in Alzheimer's disease research and aims to reduce healthcare costs.

Grant Frequency

Recurring grant opportunity with multiple application deadlines.

Organizational Aspects

Eligible Organization Types

Only United States small business concerns (SBCs) are eligible.

Specific Qualifications and Certifications Needed

Must be organized for profit and operate primarily within the United States.

Organizational Size and Capacity Requirements

Must have not more than 500 employees.

Geographic Location Requirements

Must be located in the United States.

Track Record and Experience Requirements

Must meet specific ownership and control criteria outlined in the grant.

Partnership or Consortium Requirements

Not specified.

Organizational Structure Preferences

Must be in a legal form such as corporation, partnership, or limited liability company.

Inclusivity and Diversity Considerations

Encourages research addressing disparities in care among diverse populations.

Previous Relationship with Funder Considerations

Not specified.

Organizational Maturity Requirements

Not specified.

Scope and Focus

Primary Focus Areas and Priorities

Research on prevention, diagnosis, treatment, and care for Alzheimer's disease and related dementias.

Target Sectors and Themes

Healthcare, technology development.

Target Beneficiaries and Stakeholders

Individuals living with AD/ADRD, healthcare providers, and small businesses.

Geographic Coverage Requirements

Must be based in the United States.

Scope Limitations and Exclusions

Not specified.

Expected Outcomes and Deliverables

Innovative products and services that advance progress in AD/ADRD.

Alignment Requirements with Funder Priorities

Must align with NIA's strategic plan.

Impact Expectations

Reduction in human burden and healthcare costs associated with AD/ADRD.

Project Scale Requirements

Phase I and Phase II projects.

Sustainability Expectations

Not specified.

Technical Details

Technical Expertise Requirements

Not specified.

Infrastructure Requirements

Not specified.

Team Composition and Qualification Requirements

Must include a Program Director/Principal Investigator with relevant skills.

Research Methodology Requirements

Must adhere to NIH-defined clinical trial standards if applicable.

Quality Standards and Expectations

Must comply with NIH grants policies.

Technical Documentation Requirements

Must follow SBIR/STTR application instructions.

Risk Management Expectations

Not specified.

Intellectual Property Policies

Rights to data generated during the award retained for up to 20 years.

Technology Specifications

Not specified.

Technical Partnerships Expectations

Not specified.

Security and Data Protection Requirements

Must comply with data management and sharing policies.

Technical Compliance Standards

Must comply with NIH Grants Policy Statement.

Financial Structure

Budget Range and Limitations

Phase I budgets up to $500,000; Phase II budgets up to $2.5 million.

Eligible and Ineligible Costs

Not specified.

Matching Fund Requirements and Percentages

Not specified.

Co-financing Requirements

Not specified.

Payment Schedule and Mechanisms

Not specified.

Financial Reporting Requirements

Must comply with NIH reporting requirements.

Audit Requirements

Not specified.

Financial Sustainability Expectations

Not specified.

Cost-sharing Structures

Not specified.

Indirect Cost Policies

Not specified.

Budget Flexibility Parameters

Not specified.

Financial Guarantees Required

Not specified.

Timeline and Implementation

Application Deadlines and Submission Windows

Multiple deadlines: January 5, 2023; April 5, 2023; September 5, 2023; January 5, 2024; April 5, 2024; September 5, 2024; January 5, 2025; April 5, 2025; September 5, 2025.

Grant Duration Parameters

Phase I: up to 2 years; Phase II: up to 3 years.

Implementation Timeline Expectations

Applicants are encouraged to propose a reasonable project duration.

Reporting Schedule and Frequency

Annual reporting required.

Key Milestones and Deliverables Timeline

Not specified.

Monitoring and Evaluation Requirements

Must comply with NIH monitoring requirements.

Implementation Phases Requirements

Not specified.

Extension Possibilities

Not specified.

Project Planning Requirements

Not specified.

Progress Tracking Mechanisms

Not specified.

Post-grant Period Expectations

Not specified.

Compliance and Requirements

Regulatory Compliance Requirements

Must comply with NIH Grants Policy Statement.

Required Permits and Authorizations

Not specified.

Data Protection and Privacy Regulations

Must comply with data management and sharing policies.

Environmental Compliance Requirements

Not specified.

Ethical Standards and Requirements

Must adhere to ethical standards in research.

International Collaboration Regulations

Foreign institutions are not eligible to apply.

Industry-specific Regulatory Compliance

Not specified.

Labor Standards Compliance

Not specified.

Tax Implications and Requirements

Not specified.

Reporting Compliance Requirements

Must comply with NIH reporting requirements.

Accessibility and Inclusion Standards

Not specified.

Legal Framework Compliance

Must comply with federal regulations.

Application Process

Required Documentation and Materials

Must follow the SBIR/STTR application instructions.

Application Procedure and Steps

Applications must be submitted electronically via Grants.gov.

Evaluation Criteria and Scoring System

Applications evaluated based on scientific and technical merit.

Review Process and Timeline

Applications undergo peer review and advisory council review.

Selection Criteria and Priorities

Scientific merit and alignment with NIA priorities.

Pre-application Requirements

Not specified.

Submission Format and Platform

Must use Grants.gov or NIH ASSIST system.

Supporting Materials Required

Not specified.

Interview or Presentation Requirements

Not specified.

Application Assistance Availability

eRA Service Desk available for assistance.

Resubmission Policies

Resubmissions allowed for all phases.

Special Considerations

Unique Aspects or Requirements

Encourages research addressing disparities in care.

Potential Challenges or Limitations

Not specified.

Strategic Alignment Opportunities

Aligns with NIA's strategic plan.

Competitive Advantages Factors

Not specified.

Cross-cutting Themes

Focus on diversity and inclusion in research.

Innovation Requirements or Preferences

Encourages innovative approaches to AD/ADRD.

Research Component Requirements

Must include a research component related to AD/ADRD.

Risk Tolerance and Mitigation Expectations

Not specified.

Cultural and Contextual Considerations

Not specified.

Knowledge Sharing Expectations

Not specified.

Previous Funding Patterns

Historical Grant Recipients Profile

Not specified.

Success Rate Statistics

Not specified.

Grant Size Trends

Not specified.

Recurring Grantee Patterns

Not specified.

Geographic Distribution Patterns

Not specified.

Sector Concentration Patterns

Not specified.

Emerging Priority Areas

Not specified.

Changes in Funding Criteria Over Time

Not specified.

Success Stories and Case Studies

Not specified.

Lessons Learned from Previous Cycles

Not specified.

Grant Details

alzheimer's disease dementia healthcare research small business innovation clinical trials technology transfer healthcare technology
Advancing Research on Alzheimer's Disease (AD) and AD-Related Dementias (ADRD)
PAS-22-197
Small Business Technology Transfer (STTR)
SME STARTUP
US
HEALTHCARE TECHNOLOGY
DEVELOPMENT EARLY_MARKET
0-10 11-50 51-250 251-500
SDG3
FUNDING RESEARCH_DEVELOPMENT
None
4000000.00
500000.00
2500000.00
USD
100.00
Sept. 5, 2025, 10 p.m.
March 2023 - April 2026