NCCIH Natural Product Early Phase Clinical Trial Phased Innovation Award
National Institutes of Health (NIH)
Up to $350,000 direct costs per year
Maximum of 5 years (3 years for R61 phase and 3 years for R33 phase)
To support early phase clinical trials of natural products with a strong scientific premise.
Researchers in complementary and integrative health
Participants in clinical trials
NIH funding
Grant mechanism
Recurring grant opportunity
Higher Education Institutions
Public/State Controlled Institutions of Higher Education
Private Institutions of Higher Education
Nonprofits Other Than Institutions of Higher Education
For-Profit Organizations
Small Businesses
Local Governments
State Governments
County Governments
City or Township Governments
Indian/Native American Tribal Governments (Federally Recognized)
Indian/Native American Tribal Governments (Other than Federally Recognized)
U.S. organizations only; foreign organizations are not eligible.
Clinical trials of natural products (botanicals, probiotics, dietary supplements)
Pharmacokinetics and bioavailability studies
Milestone-driven testing of natural products
Assessment of effects on specified target measures
Experience in conducting clinical trials
Knowledge of pharmacokinetics and bioavailability
Budget limited to $350,000 direct costs per year
Open Date: May 23, 2025
Application Due Dates: Various dates until October 20, 2026
Must adhere to FDA regulations for clinical research on natural products
Milestones and Go/No-Go Criteria Plan
Research Plan
Must propose a pharmacokinetic study or provide data from previous studies