NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed)
National Institutes of Health (NIH)
Application budgets are not limited but must reflect the actual needs of the proposed project.
Maximum project period is 5 years.
To support discrete, specified projects in areas representing the specific interests and competencies of the investigator(s).
To foster fundamental creative discoveries and innovative research strategies.
Investigators and researchers in health-related fields.
Participating NIH Institutes and Centers.
Eligible organization types include higher education institutions, nonprofits, for-profit organizations, local governments, state governments, and tribal governments.
Nonprofits with and without 501(c)(3) IRS status are eligible.
Eligible organizations can be based in the U.S. or be foreign organizations.
Non-domestic components of U.S. organizations are also eligible.
Projects must align with the programmatic interests of one or more participating NIH Institutes and Centers.
Applications proposing clinical trials are not accepted.
No specific budget limits, but budgets must reflect actual project needs.
Cost sharing is not required.
Application due dates are set for various cycles, with the next due date being January 7, 2028.
Applications must be submitted electronically.
The NIH will not accept duplicate or highly overlapping applications under review at the same time.
Applications must follow the instructions in the Research (R) Instructions in the How to Apply - Application Guide.
Applications will be evaluated based on overall impact, significance, innovation, rigor, and feasibility.
Applications will undergo scientific peer review and will be assigned to appropriate NIH Institutes or Centers.
Scientific and technical merit of the proposed project will be a key factor in funding decisions.
Applications must comply with NIH Grants Policy Statement and other federal regulations.
Applicants must ensure all registrations are completed prior to submission.
Applicants are encouraged to identify a participating NIH Institute that supports their area of research.
Strong emphasis on scientific integrity and public accountability may favor well-prepared applications.
Aligning project goals with NIH Institute priorities.
Submitting overlapping applications or failing to comply with application instructions.
Engage with NIH staff to clarify interests and expectations.
Highlight innovative aspects of the research and its potential impact on health.