Grant name: Effectiveness Trials to Test Mental Health System Interventions (R61/R33 Clinical Trial Required)
Funding organization: National Institutes of Health (NIH)
Total funding amount: $27 million for FY 2026
Duration: Maximum of 5 years (2 years for R61 phase, 4 years for R33 phase)
Primary objective: To support clinical trials that test system interventions to improve mental health care delivery and outcomes.
Key stakeholders: Mental health care providers, researchers, policymakers, and priority populations.
Funding source: National Institute of Mental Health (NIMH).
Funding type: Grant.
Significance: Addresses critical issues in mental health care delivery.
Grant frequency: New funding opportunity.
Higher Education Institutions
Public/State Controlled Institutions of Higher Education
Private Institutions of Higher Education
Nonprofits (with and without 501(c)(3) status)
For-Profit Organizations (including Small Businesses)
Local, State, County, City Governments
Indian/Native American Tribal Governments (both recognized and non-recognized)
Federal Government Agencies
Non-domestic (non-U.S.) Entities (Foreign Organizations)
Organizations must complete registrations with SAM, eRA Commons, and Grants.gov.
Principal Investigators must have an eRA Commons account.
System interventions targeting mental health care delivery.
Improvement of access, engagement, quality, and outcomes in mental health services.
Priority populations including racial and ethnic minorities, individuals in rural areas, and socioeconomically disadvantaged persons.
Research methodology must align with NIH-defined clinical trials.
Applications must include a detailed analytic plan.
Application budgets are not limited but must reflect actual project needs.
No cost-sharing is required.
Open Date: January 14, 2025
Application Due Dates: Various deadlines through 2027.
Expiration Date: October 16, 2027
Must comply with NIH Grants Policy Statement and other federal regulations.
Applications must follow the instructions in the How to Apply - Application Guide.
A Letter of Intent is encouraged but not required.
Applications must explicitly test how, why, for whom, and under what circumstances the system intervention may be effective.
This funding opportunity is part of a series of NOFOs addressing mental health interventions.