Microglial Pathophysiology in Comorbid Substance Use Disorder (SUD) and HIV (R61/R33 Clinical Trial Not Allowed)
National Institutes of Health (NIH)
Total budget of $2.5 million for FY 2026
Funding for 3-6 awards
To examine protein interaction networks in HIV-infected microglia and their role in SUD.
To generate brain region and cell-type specific microglial protein profiles.
Researchers in the fields of neuroscience and substance use disorders.
Institutions involved in HIV and SUD research.
Eligible organization types include higher education institutions, nonprofits, for-profit organizations, local governments, and federal agencies.
Nonprofits with and without 501(c)(3) IRS status are eligible.
Open to U.S. and non-domestic (foreign) entities.
Non-domestic components of U.S. organizations are eligible.
Focus on innovative research methodologies related to microglial protein profiling.
Applications must not propose clinical trials.
Application budgets are not limited but must reflect the actual needs of the proposed project.
Application deadline is August 14, 2025.
Projects may not exceed five years of total effort.
Applicant organizations may submit more than one application, provided each is scientifically distinct.
Applications must follow the instructions in the Research (R) Instructions in the How to Apply - Application Guide.
Applications will be evaluated based on scientific and technical merit.
Applications will undergo a peer review process by appropriate Scientific Review Groups.
Scientific merit, relevance to program priorities, and availability of funds will be considered.
Applications must adhere to the NIH Data Management and Sharing Policy.
Applications relying solely on in vitro models will not be reviewed.
Research should address significant gaps in knowledge regarding HIV and SUD comorbidities.
Innovative approaches to protein profiling may provide a competitive edge.
Strong alignment with the grant's objectives and innovative research methodologies.
Submitting applications that do not comply with the application instructions.
Engage with NIH resources and guidelines to ensure compliance.
Highlight unique aspects of the proposed research that align with NIH priorities.