Novel Mechanism Research on Neuropsychiatric Symptoms (NPS) in Alzheimer's Dementia (R01 Clinical Trial Optional)
National Institutes of Health (NIH)
Total budget is not limited but must reflect the actual needs of the proposed project.
Maximum project period is 5 years.
To enhance knowledge of mechanisms associated with neuropsychiatric symptoms in Alzheimer's disease or related dementias.
To advance mechanistic understanding of biobehavioral and neurobiological pathways leading to neuropsychiatric symptoms.
Individuals with Alzheimer's disease or related dementias.
Researchers in the fields of neuroscience, psychology, and related disciplines.
Eligible organization types include higher education institutions, nonprofits, for-profit organizations, small businesses, local governments, state governments, and tribal governments.
Nonprofits can be either with or without 501(c)(3) IRS status.
Federal government agencies and foreign organizations are also eligible.
Open to U.S. organizations and non-domestic entities.
Foreign components of U.S. organizations are allowed.
Research must focus on neuropsychiatric symptoms in Alzheimer's disease or related dementias.
Projects should aim to identify neurobiological, behavioral, and social mechanisms underlying these symptoms.
No specific budget limits, but budgets must reflect actual project needs.
Cost sharing is not required.
Application due date is September 7, 2026.
Applications must be submitted electronically via Grants.gov.
Applicants may submit more than one application as long as each is scientifically distinct.
The NIH will not accept duplicate or overlapping applications under review at the same time.
Applications must follow the instructions in the Research Instructions in the How to Apply - Application Guide.
Applications will be evaluated based on scientific and technical merit.
Review criteria include significance, innovation, rigor, and feasibility.
Applications will undergo peer review by appropriate Scientific Review Groups.
Scientific and technical merit of the proposed project.
Relevance of the proposed project to program priorities.
Research must integrate multiple levels of analysis and employ cutting-edge methodologies.
Applications that assess potential mechanisms at only a single level of observation will not be supported.
Encouragement for academic-industry collaborations.
Projects that utilize existing data or lack preliminary data may be more suitable for the companion R21 mechanism.
Strong theoretical justification for proposed approaches.
Submitting overlapping applications.
Ensure compliance with all application instructions.
Highlight innovative aspects of the proposed research.