Grants8 logo Grants8
Login Create account

Grant Details

https://www.grants.gov/search-results-detail/358116

Grant Analysis

Purpose & Target

  • This grant aims to provide small research support (R03) to current NIDDK-supported K01, K08, K23, and K25 award recipients.
  • The objective is to enhance their research capability and facilitate their transition to fully independent investigator status by allowing them to expand existing research or conduct pilot studies.
  • Target recipient type: Individual researchers (Principal Investigators) who are currently recipients of specific NIDDK K-awards.
  • Target organization types: Higher Education Institutions, Nonprofits, For-Profit Organizations (including Small Businesses), Local and Federal Governments, Independent School Districts, Public Housing Authorities, Native American Tribal Organizations, Faith-based or Community-based Organizations, Regional Organizations.
  • SECTOR-SPECIFIC: Medical Research, specifically related to the mission interests of NIDDK (National Institute of Diabetes and Digestive and Kidney Diseases).
  • Geographic scope: US-based applicant organizations. Foreign components are allowed, but the primary applicant must be domestic.
  • Key filtering criteria: Must be a current NIDDK K01/K08/K23/K25 award recipient and not have already secured an R01 or equivalent grant.
  • Grant frequency: Recurring (reissue of a previous program).

Financial Structure

  • Funding instrument: Grant (financial assistance).
  • Budget limitations: $75,000 direct costs per year.
  • Maximum project period: two years.
  • Maximum total direct costs per award: $150,000.
  • Currency: USD.
  • Cost sharing: Not required.
  • Pre-award costs: Allowable as described in the NIH Grants Policy Statement.
  • Indirect cost policies: Governed by NIH Grants Policy Statement.

Eligibility Requirements

Organizational Eligibility
  • Any of the following organization types are eligible to apply:
    • Higher Education Institutions (Public/State Controlled, Private)
    • Nonprofits (with 501(c)(3) IRS Status or without)
    • For-Profit Organizations (Small Businesses, other For-Profit)
    • Local Governments (State, County, City/Township, Special District, Indian/Native American Tribal - Federally Recognized or Other)
    • Federal Governments (Eligible Agencies, U.S. Territory or Possession)
    • Other types including Independent School Districts, Public Housing Authorities/Indian Housing Authorities, Native American Tribal Organizations (other than federally recognized tribal governments), Faith-based or Community-based Organizations, Regional Organizations.
  • Foreign (non-U.S.) organizations are not eligible to apply as the primary applicant.
  • Non-domestic (non-U.S.) components of U.S. organizations are not eligible to apply. However, foreign components, as defined in the NIH Grants Policy Statement, are allowed.
Individual (Principal Investigator/Program Director - PD/PI) Eligibility
  • Must be a current recipient of an NIDDK-supported K01, K08, K23, or K25 career development award.
  • The K award must be active at the time of the earliest intended start date of the R03 grant (this includes any no-cost extensions). Ideally, the awardee should have at least one year remaining on their K award.
  • Must not have already successfully competed for an R01, or equivalent, grant.
  • Individuals are eligible to receive only one R03 award under this specific program.
General Requirements
  • Applicant organizations must complete and maintain active registrations with:
    • System for Award Management (SAM) (annual renewal required, includes Unique Entity Identifier (UEI)).
    • eRA Commons (organization must identify at least one Signing Official and one PD/PI account).
    • Grants.gov (requires active SAM registration).
  • All PD/PIs must have an eRA Commons account and affiliate it with the applicant organization.

Application Process

Application Submission Deadlines
  • The latest application due date for new applications is October 16, 2027, 5:00 PM local time of the applicant organization.
  • The latest application due date for renewal/resubmission/revision applications is November 16, 2027, 5:00 PM local time of the applicant organization.
  • If a due date falls on a weekend or Federal holiday, the deadline is automatically extended to the next business day.
  • Applicants are encouraged to submit early to allow time for corrections.
Application Process and Materials
  • Applications must be submitted electronically via NIH ASSIST, Grants.gov Workspace, or an institutional system-to-system solution. Paper applications are not accepted.
  • Required attachments, in addition to standard application components:
    • 'K Award Information.pdf': A brief, two-page summary of the PD/PI's NIDDK-funded K-award. This should include specific aims of the K, its brief summary, and explain the relationship to the proposed R03. It must also describe how the R03 research will lead to a future research project grant (e.g., R01) and how it diverges or is informed by the K-award research.
    • 'Mentor's Letter.pdf': A letter from the K award mentor(s) (a single counter-signed letter is sufficient if multiple mentors). This letter should address the applicant's potential for a future, independent research career and describe how the mentor will facilitate the applicant's full transition to research independence.
  • Applications lacking these mandatory attachments will be considered incomplete and will not be reviewed.
  • Conformance to page limitations and all instructions in the 'How to Apply - Application Guide' is strictly enforced.
Project Implementation and Reporting
  • Project duration: Maximum two years.
  • Annual reporting: Research Performance Progress Report (RPPR) is required.
  • Financial reporting: Required financial statements.
  • Closeout requirements: Submission of a final RPPR, invention statement, and expenditure data (Federal Financial Report).
Review and Award Timeline
  • Scientific Merit Review for latest due dates (Oct/Nov 2027 applications): March 2028.
  • Advisory Council Review: May 2028.
  • Earliest Start Date: July 2028.
  • Award notices (Notice of Award - NoA) are sent to the recipient’s business official.

Evaluation Criteria

Scored Review Criteria (Factors determining scientific merit and overall impact score)
  • Factor 1: Importance of the Research (Significance and Innovation)
  • Factor 2: Rigor and Feasibility (Approach)
  • Factor 3: Expertise and Resources (Investigator(s) and Environment)
    • Investigator(s): Evaluate background, training, and expertise appropriate for their career stage. For Multiple PI applications, assess the quality of the leadership plan.
    • Environment: Evaluate if institutional resources are appropriate to ensure successful execution of the proposed work.
    • Specific to this NOFO: Evaluate the potential of the PD/PI to become an independent researcher if the proposed project is successful.
Additional Review Criteria (Considered for overall impact score, but not separately scored)
  • Protections for Human Subjects: If applicable, evaluate justification for involvement, proposed protections, potential benefits, importance of knowledge, and data/safety monitoring for clinical trials. For exempt research, evaluate justification for exemption, human subjects involvement/characteristics, and sources of materials.
  • Vertebrate Animals: If applicable, evaluate description of procedures, justifications for use/species, interventions to minimize discomfort, and justification for euthanasia.
  • Biohazards: If applicable, evaluate whether materials/procedures are significantly hazardous and if adequate protection is proposed.
  • Resubmissions: Evaluate the full application as presented.
  • Renewals: Evaluate progress made in the last funding period.
  • Revisions: Evaluate the appropriateness of the proposed expansion of the project scope.
Additional Review Considerations (Not scored, not for overall impact score, but considered)
  • Authentication of Key Biological and/or Chemical Resources: For projects involving these resources, evaluate brief plans for identifying and ensuring their validity.
  • Budget and Period of Support: Evaluate whether the budget and requested period are fully justified and reasonable in relation to the proposed research.

Compliance & Special Requirements

Regulatory and Registration Compliance
  • All applicant organizations must be registered with and maintain active registration in:
    • System for Award Management (SAM) (includes Unique Entity Identifier - UEI).
    • eRA Commons.
    • Grants.gov.
  • Non-domestic entities must obtain a NATO Commercial and Government Entity (NCAGE) code to register in SAM.
  • All Program Directors/Principal Investigators (PD/PIs) must have an eRA Commons account.
  • Compliance with 2 CFR Part 200 (Uniform Administrative Requirements, Cost Principles, and Audit Requirements for Federal Awards) is required.
  • All awards are subject to the terms and conditions described in the NIH Grants Policy Statement.
Research-Specific Compliance
  • Data Management and Sharing Plan: Required for all research generating scientific data, regardless of direct costs requested. This plan must be approved and then implemented as described.
  • Human Subjects Research: If the project involves human subjects, specific protections, ethical standards, and review (e.g., Institutional Review Board - IRB) are required. Data and safety monitoring applies for clinical trials.
  • Vertebrate Animals Research: If applicable, requires adherence to specific criteria for description of procedures, justifications for animal use, and measures to minimize discomfort.
  • Biohazards: If applicable, assessment of hazardous materials/procedures and proposed protections is required.
  • Clinical Trials: If proposing NIH-defined clinical trials, mandatory registration and results reporting on ClinicalTrials.gov is required. Investigational New Drug (IND) or Investigational Device Exemption (IDE) requirements apply if involving unapproved therapeutics/devices.
General Compliance and Other Considerations
  • Mandatory Disclosure: Recipients must submit any information related to violations of federal criminal law involving fraud, bribery, or gratuity violations potentially affecting the federal award.
  • Nondiscrimination: Recipients must comply with all applicable nondiscrimination laws, as agreed upon during SAM.gov registration, and must submit an Assurance of Compliance (HHS-690).
  • Intergovernmental Review (E.O. 12372): This initiative is not subject to intergovernmental review.
  • Limitations: Applicants may receive funding for only one R03 grant under this specific program.

Grant Details

medical research biomedical research health research diabetes digestive diseases kidney diseases endocrinology metabolic diseases hematology urology research grants career development investigator independence pilot studies feasibility studies data analysis research methodology technology development clinical trials nih funding niddk r03 grant k award recipients academic research nonprofit research for-profit research government research us federal grants scientific research biotechnology life sciences public health
Limited Competition: Small Grant Program for NIDDK K01/K08/K23/K25 Recipients (R03 Clinical Trial Optional)
PAR-25-091
National Institutes of Health (NIH)
UNIVERSITY NGO OTHER PUBLIC ENTERPRISE SME
US
HEALTHCARE
DEVELOPMENT
OTHER
SDG3 SDG4 SDG9
FUNDING RESEARCH_DEVELOPMENT CAPACITY_BUILDING
150000.00
75000.00
150000.00
USD
100.00
Nov. 16, 2027, 5 p.m.
March-May 2028