Role of Defective Proviruses in HIV Persistence (R01 Clinical Trial Not Allowed)
National Institutes of Health (NIH)
Estimated funding amount: $500,000
Maximum project period: 5 years
To support research defining the impact of defective HIV proviruses on HIV persistence and pathogenesis during antiretroviral treatment.
Researchers and institutions engaged in HIV-related studies.
Eligible organization types include higher education institutions, nonprofits, for-profit organizations, local governments, state governments, and tribal governments.
Nonprofits with and without 501(c)(3) IRS status are eligible.
Foreign organizations and non-domestic components of U.S. organizations are also eligible.
Open to U.S. and foreign organizations.
Research must focus on defective HIV proviruses and their impact on HIV persistence.
Clinical trials are not allowed; applications must include analysis of clinical samples from people living with HIV.
Application budgets are not expected to exceed $500,000 in direct costs per year.
Applications are due by 5:00 PM local time of the applicant organization.
Key dates include the opening date on April 7, 2025, and the closing date on January 7, 2028.
Applicants may submit more than one application, provided each is scientifically distinct.
Applications must follow the instructions in the Research (R) Instructions in the How to Apply - Application Guide.
Applications will be evaluated based on scientific and technical merit.
Applications will undergo peer review and be evaluated for completeness and compliance.
Applications will be selected based on scientific merit and relevance to program priorities.
Research must include analysis of clinical samples from people living with HIV.
Applications proposing clinical trials or using SIV/SHIV models will be considered non-responsive.
Research should align with NIH priorities in infectious diseases.
Strong emphasis on innovative approaches to studying HIV persistence.
Demonstrating a clear understanding of the impact of defective HIV proviruses.
Submitting applications that do not comply with the specific requirements outlined in the NOFO.
Engage with NIH contacts for guidance on application preparation.
Highlight unique methodologies and potential for impactful research outcomes.