NIH Exploratory/Developmental Research Project Grant
National Institutes of Health (NIH)
The combined budget for direct costs for the two-year project period may not exceed $275,000.
No more than $200,000 may be requested in any single year.
To support exploratory and developmental research projects.
To foster fundamental creative discoveries and innovative research strategies.
Participating NIH Institutes and Centers.
Researchers in biomedical, behavioral, and clinical fields.
Eligible organization types include higher education institutions, nonprofits, for-profit organizations, local governments, and tribal governments.
Nonprofits with and without 501(c)(3) IRS status are eligible.
Non-domestic (non-U.S.) entities are eligible to apply.
Foreign components of U.S. organizations are allowed.
Proposals must include at least one clinical trial.
Projects should be exploratory and novel, distinct from traditional R01 applications.
The budget for direct costs may not exceed $275,000 over two years.
No more than $200,000 may be requested in any single year.
Applications are due by 5:00 PM local time of the applicant organization.
The earliest submission date is January 16, 2025, with a closing date of January 7, 2028.
Applicants may submit more than one application, provided each is scientifically distinct.
The NIH will not accept duplicate or highly overlapping applications.
Applications must follow the instructions in the Research (R) Instructions in the How to Apply - Application Guide.
Applications will be evaluated for scientific and technical merit.
Reviewers will consider significance, innovation, rigor, and feasibility.
Applications will undergo peer review and may receive a second level of review by the appropriate national Advisory Council or Board.
Scientific and technical merit of the proposed project will be a primary consideration.
The grant requires that at least one clinical trial be proposed.
Applications must comply with specific NIH policies and guidelines.
Projects should align with the programmatic interests of participating NIH Institutes and Centers.
Innovative and exploratory projects may have a competitive advantage.
Proposals should demonstrate innovation and potential for significant impact.
Avoid submitting overlapping applications.
Engage with NIH staff to ensure alignment with IC interests.
Highlight the novelty and exploratory nature of the research.