Grant Details

GRANT OVERVIEW

Grant Details

Funding organization: National Institutes of Health (NIH)

Total funding amount: $1,000,000

Duration: Up to 5 years

Primary objective: Support preclinical testing of drug candidates for AD/ADRD

Key stakeholders: Higher education institutions, nonprofits, government entities

Beneficiaries: Researchers and patients affected by AD/ADRD

ELIGIBILITY CRITERIA

Organization Requirements

Eligible organization types include higher education institutions, nonprofits, for-profit organizations, local and state governments, and tribal governments.

Nonprofits must have or not have 501(c)(3) status.

Foreign organizations are eligible to apply.

Geographic Scope

Eligible applicants can be from the U.S. or foreign organizations.

Non-domestic components of U.S. organizations are allowed.

Project Requirements

Projects must focus on preclinical testing of drugs for AD/ADRD.

Applications should propose a streamlined preclinical testing strategy.

Collaboration with industry partners is encouraged.

Financial Requirements

Application budgets are capped at $1 million in direct costs per year.

No cost-sharing is required.

Timeline Requirements

Application due date: May 7, 2028.

Earliest start date for funded projects: June 9, 2025.

Previous Funding Considerations

Applicants may submit more than one application, provided each is scientifically distinct.

The NIH will not accept duplicate or overlapping applications.

APPLICATION PROCESS

Required Documentation

Applications must follow the instructions in the Research (R) Instructions in the How to Apply - Application Guide.

All required registrations must be completed prior to submission.

Evaluation Criteria

Applications will be evaluated based on scientific merit, significance, innovation, rigor, and feasibility.

Review Process

Applications will undergo peer review by appropriate Scientific Review Groups.

SPECIAL CONSIDERATIONS

Unique Aspects

Projects must adhere to open-science principles and maximize data sharing.

Potential Challenges

Applications proposing only bioinformatics approaches will be considered non-responsive.

KEY INSIGHTS AND RECOMMENDATIONS

Critical Success Factors

Collaboration with experienced researchers in preclinical drug development is crucial.

Common Pitfalls to Avoid

Avoid submitting overlapping applications.

Grant Details

alzheimer's disease dementia drug repositioning combination therapy preclinical testing biomedical research healthcare neurodegenerative diseases
Translational Bioinformatics and Experimental Approaches to Advance Drug Repositioning and Combination Therapy Development for Alzheimer's Disease and Related Dementias (R01 Clinical Trial Not Allowed)
PAR-25-374
NIH Grants
EDU NGO ENTERPRISE PUBLIC OTHER
US AF AL DZ AS AD AO AI AQ AG AR AU AT BY BE BG CA CN HR CY CZ DK EG EE FI FR GE DE GI GR HU IS IE IL IT JP LV LI LT LU MK MY MT MX MD NL NZ NO PL PT QA RO SA SC SG SK SI ES SE CH TR UA AE UK VA VG VI
RESEARCH_DEVELOPMENT
False
1000000.00
None
1000000.00
USD
100.00
True
False
Establish robust proof of concept for drug repositioning and combination therapy for AD/ADRD.
Preclinical testing results and data shared via the AD Knowledge Portal.
May 7, 2028, 10 p.m.
Not specified
Follow the instructions in the Research (R) Instructions in the How to Apply - Application Guide.
True
Overall impact score based on scientific merit.
Significance and innovation of the proposed research.
Rigor and feasibility of the proposed approach.
Potential for sustained influence on the research field.
False
False
Grant
Compliance with NIH Grants Policy Statement.
Annual RPPR and financial statements as required.
Details of payment arrangements will be outlined in the Notice of Award.
NIH Grants Policy Statement applies.
Adherence to open-science principles and data sharing.