Grant name: Functional Validation and/or Characterization of Genes or Variants Implicated in Substance Use Disorders
Funding organization: National Institutes of Health (NIH), National Institute on Drug Abuse (NIDA)
Total funding amount: Up to $125,000 per year for R21 phase; up to $250,000 per year for R33 phase
Duration: R21 phase up to 2 years; R33 phase up to 3 years; total project period not exceeding 5 years
Primary objective: Support projects that functionally validate and/or characterize genes or variants involved in substance use disorders
Funding source: Federal government
Significance: Addresses critical gaps in understanding the neurobiological mechanisms of addiction
Grant frequency: Recurring
Higher Education Institutions
Public/State Controlled Institutions of Higher Education
Private Institutions of Higher Education
Nonprofits (with and without 501(c)(3) status)
For-Profit Organizations (including Small Businesses)
Local, State, County, City Governments
Indian/Native American Tribal Governments (both Federally Recognized and not)
Federal Government Agencies
U.S. Territories
Other entities including Independent School Districts, Public Housing Authorities, Faith-based Organizations, and Foreign Organizations
Organizations must complete registrations with SAM, eRA Commons, and Grants.gov prior to application submission
All Principal Investigators must have an eRA Commons account
Functional validation and characterization of addiction-relevant genes or variants
Research must include exposure to addictive substances relevant to NIDA
Research teams with expertise in substance use disorder (SUD) relevant science
Research teams should demonstrate capability in proposed techniques or assays
No preliminary data required, but justification based on scientific literature is necessary
R21 phase budget cannot exceed $125,000 per year
R33 phase budget cannot exceed $250,000 per year
Open Date: February 3, 2025
Application Due Date: July 28, 2025
Earliest Start Date: March 3, 2025
Must adhere to NIH Grants Policy Statement and federal regulations
No cost sharing required
Applications must be submitted electronically via Grants.gov
Letter of Intent is encouraged but not required