Development and Testing of Novel Interventions to Improve HIV Prevention, Treatment, and Program Implementation for People Who Use Substances (R34 Clinical Trial Required)
National Institutes of Health (NIH)
Direct costs of up to $450,000 for a maximum project period of three years.
To support formative research, intervention development, and pilot-testing of interventions targeting HIV prevention and treatment for individuals who use drugs.
Individuals who use substances, healthcare providers, and organizations involved in HIV prevention and treatment.
Eligible organization types include higher education institutions, nonprofits, for-profit organizations, local governments, state governments, and federal agencies.
Foreign organizations are also eligible to apply.
Applications from U.S. and non-U.S. entities are accepted.
Focus on formative research, intervention development, and pilot-testing of interventions for HIV prevention and treatment.
Interventions may include behavioral, social, or structural approaches.
Direct costs may not exceed $450,000 over three years, with no more than $225,000 in any single year.
Applications are due by May 7, 2027, with an opening date for submissions on April 7, 2025.
No restrictions on prior grant funding mentioned.
Applications must follow the instructions in the Research (R) Instructions in the How to Apply - Application Guide.
Applications will be evaluated based on scientific and technical merit, including significance, innovation, and approach.
Applications will undergo peer review and may receive a second level of review by the appropriate national Advisory Council or Board.
Scientific and technical merit, availability of funds, and relevance to program priorities will be considered.
Engagement of end users in the research process is emphasized.
Applications focusing solely on the development of intervention protocols without testing will not be reviewed.
Applicants are encouraged to consult NIH HIV priorities and NIDA's HIV priorities.
Strong evidence of capability to conduct the proposed study is encouraged.
Engagement of relevant end users and a well-supported theory of change are critical.
Avoid applications that do not integrate substance use into study aims.
Provide strong evidence of resources and experience in conducting related studies.
Highlight unique aspects of the proposed intervention and its relevance to current HIV challenges.