Schizophrenia and related disorders during mid- to late-life (R21 Clinical Trial Optional)
National Institutes of Health (NIH)
Maximum project period: 2 years
Combined budget for direct costs: $275,000
To advance translational research on schizophrenia and related disorders in mid to late life.
To identify mechanisms underlying the emergence and trajectory of these disorders.
Individuals aged 35 and older with schizophrenia and related disorders.
Research teams from diverse backgrounds.
Eligible organization types include higher education institutions, nonprofits, for-profit organizations, small businesses, local governments, state governments, and tribal governments.
Non-domestic (non-U.S.) entities are eligible to apply.
Open to U.S. and non-U.S. organizations.
Research must focus on schizophrenia and related psychotic disorders in mid to late life.
Studies should identify mechanisms for prevention and intervention development.
No cost-sharing required.
Maximum budget for direct costs: $275,000.
Application due dates: January 16, 2025; June 16, 2025; October 16, 2025; February 16, 2026; June 16, 2026.
All applications are due by 5:00 PM local time of applicant organization.
Applicant organizations may submit more than one application, provided each is scientifically distinct.
Follow instructions in the Research (R) Instructions in the How to Apply - Application Guide.
Applications will be evaluated based on significance, innovation, rigor, and feasibility.
Applications will undergo peer review and be evaluated for scientific and technical merit.
Applications deemed to have the highest scientific merit will be prioritized.
Encouragement of teams led by or including individuals with lived experience of psychosis.
Research must not target populations less than 35 years of age.
Research that addresses minority health and health disparities is encouraged.
Innovative projects with high risk/high reward potential are favored.
Strong justification for proposed research and adherence to guidelines.
Submitting applications that do not comply with the application instructions.
Engage diverse research teams and leverage interdisciplinary approaches.
Highlight innovative aspects and potential impact of the proposed research.