Funding Organization: National Institutes of Health (NIH)
Total Funding Amount: Up to $275,000 for a two-year project period
Primary Objective: To support exploratory and developmental research projects involving basic science experimental studies with human participants.
Key Stakeholders: NIH, participating Institutes and Centers, researchers, and human participants.
Eligible organization types include higher education institutions, nonprofits, for-profit organizations, small businesses, local and state governments, and tribal governments.
Non-domestic (non-U.S.) entities are eligible to apply.
Organizations must complete necessary registrations (e.g., SAM, eRA Commons) before application submission.
Applications are accepted from U.S. and non-domestic entities.
Foreign components of U.S. organizations are allowed.
Projects must propose basic science experimental studies involving human participants.
Studies should align with NIH's definition of clinical trials and basic research.
Applications must be novel and exploratory, breaking new ground in research.
The combined budget for direct costs may not exceed $275,000 over two years.
No more than $200,000 may be requested in any single year.
Application deadlines are set for various cycles, with the next due date on January 7, 2028.
Projects may last up to two years.
Applicants may submit more than one application, provided each is scientifically distinct.
The NIH will not accept duplicate or overlapping applications under review at the same time.
Applications must follow the instructions in the Research (R) Instructions in the How to Apply - Application Guide.
Specific forms and documents must be submitted electronically through Grants.gov.
Applications will be evaluated based on scientific and technical merit, including significance, innovation, rigor, and feasibility.
Applications will undergo peer review and be assigned an overall impact score.
The NIH will consider the scientific merit and relevance to program priorities in funding decisions.
The grant supports high-risk, high-reward research that may lead to significant breakthroughs.
Applications must propose studies that do not have specific applications towards processes or products in mind.
Applicants must ensure compliance with all application instructions to avoid delays or rejection.
Emphasize innovation and the potential impact of the proposed research.
Clearly articulate the significance and feasibility of the project.
Avoid submitting overlapping applications.
Ensure all required registrations are completed before the submission deadline.