NIH Research Project Grant (Parent R01 Clinical Trial Required)
National Institutes of Health (NIH)
Funding amount is not limited but must reflect the actual needs of the proposed project.
Maximum project period is 5 years.
To support discrete, specified projects that include at least one clinical trial.
To foster fundamental discoveries and innovative research strategies that improve health.
Investigators and researchers in health-related fields.
Participating NIH Institutes and Centers.
Eligible organization types include higher education institutions, nonprofits, for-profit organizations, local and state governments, and tribal governments.
Nonprofits can be with or without 501(c)(3) status.
Foreign organizations are also eligible to apply.
Open to U.S. and non-U.S. entities.
Foreign components of U.S. organizations are allowed.
Projects must propose at least one clinical trial.
Research must align with the scientific missions of participating NIH Institutes and Centers.
Application budgets are not limited but must reflect actual project needs.
No cost-sharing is required.
Applications are due by 5:00 PM local time of the applicant organization.
Key dates include application due dates and review cycles.
Applicants may submit more than one application, provided each is scientifically distinct.
Duplicate applications are not accepted.
Applications must follow the instructions in the Research (R) Instructions in the How to Apply - Application Guide.
Specific forms and documents must be submitted electronically.
Applications are evaluated for scientific and technical merit.
Review criteria include significance, innovation, rigor, and feasibility.
Applications undergo peer review and are assigned to appropriate NIH Institutes or Centers.
Funding decisions are based on scientific merit, availability of funds, and relevance to program priorities.
All applications must propose clinical trials.
Some NIH Institutes only accept mechanistic studies.
Applicants must ensure compliance with all application instructions to avoid delays or rejection.
Applicants are encouraged to contact relevant NIH staff for guidance on aligning projects with NIH interests.
Strong emphasis on innovative research can provide a competitive edge.
Clear alignment with NIH scientific missions.
Strong research design and methodology.
Submitting duplicate applications.
Failing to comply with application guidelines.
Engage with NIH staff early in the application process.
Ensure all registrations are completed before submission.
Highlight innovative aspects of the proposed research.